Dussault J H, Labrie F
Endocrinology. 1975 Nov;97(5):1321-4. doi: 10.1210/endo-97-5-1321.
The hypothalmic content of thyrotropin-releasing hormone (TRH), the pituitary concentration of thyroid-stimulating hormone (TSH), and the serum concentrations of TSH, thyroxine (T4), and triiodothyronine (T3) have been determined at different intervals during the first 50 days following birth in the rat. From a minimum concentration of 1 pg/mug protein at birth, the hypothalamic concentration of TRH increased to a maximum of 5 to 6 pg between 16 and 28 days of age. Serum and pituitary TSH concentrations increased to maximum levels by the end of the first post-natal week; the elevated hormone levels were then maintained to the end of the third post-natal week. Circulating thyroid hormone concentrations were very low at birth. T4 increased rapidly between days 4 and 16 to reach a peak concentration of 6 mug/100 ml, while T3 followed a parallel pattern with a peak concentration of 108 ng/100 ml obtained only at day 28. These data indicate that, in the rat, components of the hypothalamic-pituitary-thyroid axis develop simultaneously during the post-natal period.
在大鼠出生后的前50天内，于不同时间间隔测定了促甲状腺激素释放激素（TRH）的下丘脑含量、促甲状腺激素（TSH）的垂体浓度以及血清中TSH、甲状腺素（T4）和三碘甲状腺原氨酸（T3）的浓度。出生时TRH的下丘脑浓度最低，为1 pg/μg蛋白质，在16至28日龄之间升至最高，达5至6 pg。血清和垂体TSH浓度在出生后第一周结束时升至最高水平；然后激素水平升高状态维持到出生后第三周结束。出生时循环甲状腺激素浓度非常低。T4在第4天至16天之间迅速升高，达到峰值浓度6 μg/100 ml，而T3呈现平行变化模式，仅在第28天达到峰值浓度108 ng/100 ml。这些数据表明，在大鼠中，下丘脑-垂体-甲状腺轴的各组成部分在出生后时期同时发育。
