Lotz P, Heise U, Schäffer J, Wollinsky K H
Anaesthesist. 1984 Apr;33(4):177-88.
The problem of how to improve postoperative pulmonary function after upper abdominal surgery was investigated in a randomized study involving 64 patients who were subjected to various treatment regimens designed to increase airway pressure. Intraoperative ventilation was carried out with either zero or positive end exspiratory pressure, and postoperatively either CPAP or a nasal oxygen catheter were applied. The following groups were formed: 1. ZEEP /O2-catheter; 2. PEEP/O2-catheter; 3. ZEEP /CPAP; 4. PEEP/CPAP. The typical reduction in vital capacity occurred postoperatively, the lowest value being recorded on the 2nd postoperative day, an alteration in respiratory pattern with reduced tidal volume and increased respiratory rate together with an initially low, later normal alveolar ventilation, and an initial hypoxaemia which was at first associated with a moderate hypercapnia, on the second postoperative day with a normocapnia, were observed. At no point in time could a difference be found between the 4 groups, no measurable improvement in respiratory function being found as a result of the treatment given. Intra- and post-operative increase in airway pressure was however found to be associated with a reduction in the incidence of post-operative pulmonary complications.
在一项随机研究中,对64例接受旨在增加气道压力的各种治疗方案的患者进行了调查,以探讨如何改善上腹部手术后的肺功能。术中通气采用呼气末正压为零或正压,术后应用持续气道正压通气(CPAP)或鼻氧导管。形成了以下几组:1. 零呼气末正压/氧导管;2. 呼气末正压/氧导管;3. 零呼气末正压/持续气道正压通气;4. 呼气末正压/持续气道正压通气。术后肺活量出现典型下降,术后第2天记录到最低值,观察到呼吸模式改变,潮气量减少,呼吸频率增加,最初肺泡通气量低,随后正常,术后最初存在低氧血症,最初伴有中度高碳酸血症,术后第2天为正常碳酸血症。在任何时间点,4组之间均未发现差异,未发现所给予的治疗导致呼吸功能有可测量的改善。然而,术中及术后气道压力增加与术后肺部并发症发生率降低有关。