人体血液的碳氧血红蛋白与氧亲和力

Carboxyhemoglobin and oxygen affinity of human blood.

作者信息

Rovida E, Niggeler M, Carlone S, Samaja M

出版信息

Clin Chem. 1984 Jul;30(7):1250-1.

Abstract

We determined normal human blood p50 at various pH values (range 7.0 to 7.6) as a function of the proportion of carboxyhemoglobin (COHb) in total hemoglobin, from 0 to 23%. The d(log p50)/d[COHb] coefficient is 0.00848, independent of pH and 2,3-diphosphoglycerate. The derived equation allows the calculation of p50 as a function of COHb with an approximation of +/- 0.54 mmHg (about 72 Pa), and can be combined with other calculations (Clin Chem 27:1856-1861, 1981; Clin Chem 29:110-114, 1983) to predict p50 under any condition of pH within the range 7.0-7.6, ratio of [2,3-diphosphoglycerate] to [total hemoglobin] (range 0.3-2.5), pCO2 (range 20-90 mmHg), temperature (range 19-43 degrees C), and COHb (range 0-23%).

摘要

我们测定了正常人体血液在不同pH值（范围为7.0至7.6）下的p50，其为总血红蛋白中羧基血红蛋白（COHb）比例（范围为0至23%）的函数。d(log p50)/d[COHb]系数为0.00848，与pH值和2,3 - 二磷酸甘油酸无关。推导得出的方程可用于计算作为COHb函数的p50，其近似误差为±0.54 mmHg（约72 Pa），并且可与其他计算方法（《临床化学》27:1856 - 1861，1981；《临床化学》29:110 - 114，1983）相结合，以预测在pH值7.0 - 7.6范围内、[2,3 - 二磷酸甘油酸]与[总血红蛋白]的比例（范围为0.3 - 2.5）、pCO2（范围为20 - 90 mmHg）、温度（范围为19 - 43摄氏度）以及COHb（范围为0 - 23%）的任何条件下的p50。