D'Angelo A, Micossi P, Mannucci P M, Garimberti B, Franchi F, Pozza G
Eur J Clin Invest. 1984 Apr;14(2):83-6. doi: 10.1111/j.1365-2362.1984.tb02092.x.
Platelet thromboxane B2 production was studied in forty-seven non-insulin-dependent diabetics by incubating platelets with increasing concentrations of arachidonic acid. In comparison with thirty-two healthy subjects, diabetics showed increased thromboxane B2 production at 0.7 mmol/l (mean: 236 pmol/10(8) platelets, SEM 201-277; v. 135, 105-174; P less than 0.05) and at 1.0 mmol/l (673, 613-739; v. 405, 377-486, P less than 0.01) but not at 0.5 mmol/l. Patients were subdivided according to the presence or absence of vascular complications. Patients without microangiopathy showed significantly greater thromboxane B2 production than healthy subjects at all the arachidonic-acid concentrations (P less than 0.02 or less). Patients with microangiopathy had platelet thromboxane production similar to that observed in healthy subjects at all the arachidonic-acid concentrations (P greater than 0.30) but significantly lower than that of non-microangiopathic patients at 0.5 (P less than 0.01) and at 0.7 mmol/l arachidonic acid (P less than 0.05). These results indicate that non-insulin-dependent diabetics have increased production of platelet thromboxane B2 only when they do not have microvascular complications.
通过将血小板与浓度不断增加的花生四烯酸一起孵育，对47名非胰岛素依赖型糖尿病患者的血小板血栓素B2生成情况进行了研究。与32名健康受试者相比，糖尿病患者在花生四烯酸浓度为0.7 mmol/l时血栓素B2生成增加（平均值：236 pmol/10⁸血小板，标准误201 - 277；对比135，105 - 174；P < 0.05），在1.0 mmol/l时也增加（673，613 - 739；对比405，377 - 486，P < 0.01），但在0.5 mmol/l时未增加。根据是否存在血管并发症对患者进行了细分。无微血管病变的患者在所有花生四烯酸浓度下的血栓素B2生成均显著高于健康受试者（P < 0.02或更低）。有微血管病变的患者在所有花生四烯酸浓度下的血小板血栓素生成与健康受试者相似（P > 0.30），但在花生四烯酸浓度为0.5 mmol/l（P < 0.01）和0.7 mmol/l时（P < 0.05）显著低于无微血管病变的患者。这些结果表明，非胰岛素依赖型糖尿病患者只有在没有微血管并发症时血小板血栓素B2生成才会增加。
