Tremoli E, Maderna P, Colli S, Morazzoni G, Sirtori M, Sirtori C R
Eur J Clin Invest. 1984 Oct;14(5):329-33. doi: 10.1111/j.1365-2362.1984.tb01191.x.
Platelet aggregation induced by collagen, ADP and epinephrine, was monitored in 150 type-II patients (115 type IIA and 35 type IIB) and compared with a reference group of normolipidaemic controls; in addition, malondialydehyde formation and thromboxane B2 were examined in a subsample of the type-IIA patients. Threshold aggregatory concentrations were significantly lower in the whole group of type-II patients for all three aggregating agents; no difference in terms of aggregatory response was detected between platelets from type-IIA and -IIB patients. Only 56% of type-II patients, however, exceeded the 95th percentile of the threshold aggregatory concentrations in controls. The formation of malondialdehyde in platelet-rich plasma stimulated with thrombin and collagen, was significantly higher in platelets from type-IIA patients. The production of thromboxane B2 by platelets, from endogenous arachidonic acid in type-IIA patients, was significantly higher and exceeded the highest level found in controls.
对150名II型患者（115名IIA型和35名IIB型）监测了由胶原蛋白、二磷酸腺苷（ADP）和肾上腺素诱导的血小板聚集情况，并与血脂正常的对照组进行比较；此外，还对IIA型患者的一个子样本检测了丙二醛的形成和血栓素B2。对于所有三种聚集剂，II型患者全组的阈值聚集浓度显著更低；未检测到IIA型和IIB型患者的血小板在聚集反应方面存在差异。然而，只有56%的II型患者超过了对照组阈值聚集浓度的第95百分位数。在用凝血酶和胶原蛋白刺激的富含血小板血浆中，IIA型患者的血小板丙二醛形成显著更高。IIA型患者血小板由内源性花生四烯酸产生的血栓素B2显著更高，且超过了对照组中发现的最高水平。
