Ensing K, de Zeeuw R A
Eur J Respir Dis Suppl. 1984;135:143-6.
The development of a radioreceptor assay for the quaternary anticholinergic drug, oxyphenonium, in plasma is reported. It is based on competition between this drug and 3H-dexetimide for binding to muscarinic receptors. After ion pair extraction and reextraction, the drug can be determined in plasma at concentrations down to a value of 100 pg/ml. This permits pharmacokinetic studies to be made after inhalation of oxyphenonium.
本文报道了一种用于测定血浆中季铵类抗胆碱能药物奥芬溴铵的放射受体分析法。该方法基于奥芬溴铵与3H-右旋美托咪啶竞争结合毒蕈碱受体。经过离子对萃取和再萃取后，可测定血浆中低至100 pg/ml浓度的该药物。这使得在吸入奥芬溴铵后能够进行药代动力学研究。
