Harrell L E, Barlow T S, Miller M, Haring J H, Davis J N
Exp Neurol. 1984 Jul;85(1):69-77. doi: 10.1016/0014-4886(84)90161-4.
To assess the role of hippocampal norepinephrine in learning and memory, rats were treated with medial septal injections of 6-hydroxydopamine either prior to or after acquisition of a spatial-memory task. No effect on acquisition learning or retention was observed. However, reversal learning was significantly enhanced in all treated animals regardless of whether treatment was prior to or after acquisition. Our results do not support a role of hippocampal norepinephrine in selective attention, but rather indicate a direct involvement in memory processes.
为评估海马去甲肾上腺素在学习和记忆中的作用，在大鼠获取空间记忆任务之前或之后，通过内侧隔注射6-羟基多巴胺对其进行处理。未观察到对获取学习或记忆保持有影响。然而，无论处理是在获取之前还是之后，所有接受处理的动物的逆向学习均显著增强。我们的结果不支持海马去甲肾上腺素在选择性注意中起作用，而是表明其直接参与记忆过程。
