非妊娠人类子宫的花生四烯酸代谢
Arachidonic acid metabolism by the non-pregnant human uterus.
作者信息
Demers L M, Rees M C, Turnbull A C
出版信息
Prostaglandins Leukot Med. 1984 May;14(2):175-80. doi: 10.1016/0262-1746(84)90199-9.
Arachidonic acid metabolism in the non-pregnant human uterus was studied using short term incubations of human endometrium and myometrium with [14C] arachidonic acid followed by HPLC separation of the arachidonic acid metabolites formed. Lipoxygenase as well as cyclooxygenase activity was found in both the endometrium and myometrium although the endometrium predominated in arachidonic acid product formation. The lipoxygenase products formed by these tissues included the monohydroxy acids 5-HETE and 12-HETE.
利用人子宫内膜和子宫肌层与[14C]花生四烯酸进行短期孵育，随后通过高效液相色谱法分离所形成的花生四烯酸代谢产物，对非妊娠人子宫中的花生四烯酸代谢进行了研究。在子宫内膜和子宫肌层中均发现了脂氧合酶以及环氧化酶活性，尽管在花生四烯酸产物形成方面子宫内膜占主导。这些组织形成的脂氧合酶产物包括单羟基酸5-羟基二十碳四烯酸（5-HETE）和12-羟基二十碳四烯酸（12-HETE）。
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