患病牙周组织匀浆通过脂氧合酶和环氧化酶途径对花生四烯酸的相对转化

Relative conversion of arachidonic acid through lipoxygenase and cyclooxygenase pathways by homogenates of diseased periodontal tissues.

作者信息

El Attar T M, Lin H S

出版信息

J Oral Pathol. 1983 Feb;12(1):7-10. doi: 10.1111/j.1600-0714.1983.tb00311.x.

DOI:10.1111/j.1600-0714.1983.tb00311.x

Abstract

The present study shows that 14C-arachidonic acid metabolism in gingiva of patients with periodontal disease is mainly via the lipoxygenase pathway. In two pools of gingival tissue homogenates, the lipoxygenase products contained 22.65% and 23.38%, while the prostaglandins (PGs), products of the cyclooxygenase pathway, contained only 4.85% and 3.98% of the total radioactivity incubated. 12-hydroxy-eicosatetraenoic acid (12-HETE), a lipoxygenase product, was detected as a major metabolite of arachidonic acid in gingiva.

摘要

本研究表明，牙周病患者牙龈中14C-花生四烯酸代谢主要通过脂氧合酶途径。在两池牙龈组织匀浆中，脂氧合酶产物分别占总放射性孵育量的22.65%和23.38%，而环氧化酶途径产物前列腺素（PGs）仅占4.85%和3.98%。12-羟基-二十碳四烯酸（12-HETE）作为脂氧合酶产物，被检测为牙龈中花生四烯酸的主要代谢物。