El Attar T M, Lin H S
J Oral Pathol. 1983 Feb;12(1):7-10. doi: 10.1111/j.1600-0714.1983.tb00311.x.
The present study shows that 14C-arachidonic acid metabolism in gingiva of patients with periodontal disease is mainly via the lipoxygenase pathway. In two pools of gingival tissue homogenates, the lipoxygenase products contained 22.65% and 23.38%, while the prostaglandins (PGs), products of the cyclooxygenase pathway, contained only 4.85% and 3.98% of the total radioactivity incubated. 12-hydroxy-eicosatetraenoic acid (12-HETE), a lipoxygenase product, was detected as a major metabolite of arachidonic acid in gingiva.
本研究表明，牙周病患者牙龈中14C-花生四烯酸代谢主要通过脂氧合酶途径。在两池牙龈组织匀浆中，脂氧合酶产物分别占总放射性孵育量的22.65%和23.38%，而环氧化酶途径产物前列腺素（PGs）仅占4.85%和3.98%。12-羟基-二十碳四烯酸（12-HETE）作为脂氧合酶产物，被检测为牙龈中花生四烯酸的主要代谢物。
