肾上腺髓质神经节苷脂

Adrenal medulla gangliosides.

作者信息

Sekine M, Ariga T, Miyatake T

出版信息

Adv Exp Med Biol. 1984;174:103-10. doi: 10.1007/978-1-4684-1200-0_9.

Abstract

The gangliosides were examined in adrenal glands of mouse, rat, guinea pig, rabbit, monkey, pig, ox and chicken. GM3 ganglioside was predominant in all examined animals except pig. In pig GD3 ganglioside was the major one. GM4 ganglioside was found in guinea pig and chicken. The distribution of sialic acid varied in each species. NeuNGly containing gangliosides were not detected in rat, guinea pig, rabbit and chicken. The other animals have both NeuNAc and NeuNGly containing gangliosides. Chromaffin granules from bovine adrenal medulla contain gangliosides at concentrations 3 and 7 times as great as microsomal and mitochondrial fractions, respectively. These gangliosides were NeuNAc-containing GM3 and NeuNGly containing GM3 in the same amount.

摘要

对小鼠、大鼠、豚鼠、兔子、猴子、猪、牛和鸡的肾上腺中的神经节苷脂进行了检测。除猪以外，GM3神经节苷脂在所有检测的动物中占主导地位。在猪中，GD3神经节苷脂是主要的。在豚鼠和鸡中发现了GM4神经节苷脂。唾液酸的分布在每个物种中都有所不同。在大鼠、豚鼠、兔子和鸡中未检测到含有NeuNGly的神经节苷脂。其他动物同时含有含有NeuNAc和NeuNGly的神经节苷脂。来自牛肾上腺髓质的嗜铬颗粒所含神经节苷脂的浓度分别是微粒体和线粒体部分的3倍和7倍。这些神经节苷脂分别是等量的含NeuNAc的GM3和含NeuNGly的GM3。