噬菌体分型和耐药模式作为分枝杆菌流行病学中的工具。
Phage-typing and drug-resistance patterns as tools in mycobacterial epidemiology.
作者信息
Gruft H, Johnson R, Claflin R, Loder A
出版信息
Am Rev Respir Dis. 1984 Jul;130(1):96-7. doi: 10.1164/arrd.1984.130.1.96.
Phage-typing by itself was not sufficient to delineate the boundaries of a mini-epidemic of tuberculosis in upstate New York. Drug-resistance patterns were needed as well. In a small upstate community, 79% of 14 isolates tested were resistant to one or more of the antituberculosis drugs. Of 15 isolates with phage types determined, 47% were type 1(13), 27% were type 7(7, 13), and 27% were type 1(7, 12, 13). By combining phage-typing and sensitivity testing, we were able to demonstrate that 4 or possibly 5 of the 7 phage-type 1(13) strains are epidemiologically related.
仅靠噬菌体分型不足以界定纽约州北部一场结核病小范围流行的边界。还需要耐药模式。在纽约州北部的一个小社区，检测的14株分离菌中有79%对一种或多种抗结核药物耐药。在已确定噬菌体类型的15株分离菌中，47%为1型（13），27%为7型（7、13），27%为1型（7、12、13）。通过将噬菌体分型与敏感性检测相结合，我们能够证明7株1型（13）菌株中有4株或可能5株在流行病学上有关联。
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