四胺类霉菌毒素环匹阿尼酸的致突变性
Mutagenicity of tetramic mycotoxin cyclopiazonic acid.
作者信息
Sorenson W G, Tucker J D, Simpson J P
出版信息
Appl Environ Microbiol. 1984 Jun;47(6):1355-7. doi: 10.1128/aem.47.6.1355-1357.1984.
Abstract
Cyclopiazonic acid was shown to be mutagenic to Salmonella typhimurium TA98 and TA100 in the presence of metabolic activation. The activity of cyclopiazonic acid in the presence of aflatoxin B1 was studied in complete factorial experiments with strain TA98. Both mycotoxins produced significant mutagenic activity and in combination. The activity in combination appeared to be additive rather than synergistic. The specific activity of cyclopiazonic acid was estimated to be approximately 140 revertants per mu mol in strain TA98.
摘要
在代谢激活存在的情况下，环匹阿尼酸对鼠伤寒沙门氏菌TA98和TA100显示出致突变性。在使用TA98菌株的完全析因实验中，研究了环匹阿尼酸在黄曲霉毒素B1存在时的活性。两种霉菌毒素单独及联合使用时均产生显著的致突变活性。联合使用时的活性似乎是相加的，而非协同的。环匹阿尼酸在TA98菌株中的比活性估计约为每微摩尔140个回复突变体。
相似文献
1
Mutagenicity of tetramic mycotoxin cyclopiazonic acid.四胺类霉菌毒素环匹阿尼酸的致突变性
Appl Environ Microbiol. 1984 Jun;47(6):1355-7. doi: 10.1128/aem.47.6.1355-1357.1984.
2
The mutagenicity of aflatoxin Q1 to Salmonella typhimurium TA 100 with or without rat or human liver microsomal preparations.黄曲霉毒素Q1在有或无大鼠或人肝微粒体制剂存在的情况下对鼠伤寒沙门氏菌TA 100的致突变性。
Res Commun Chem Pathol Pharmacol. 1986 Oct;54(1):101-13.
3
Interaction of aflatoxin B1 and cyclopiazonic acid toxicities.黄曲霉毒素B1与环匹阿尼酸毒性的相互作用。
Mol Toxicol. 1987 Jan-Mar;1(1):95-106.
4
The direct mutagenicity of aflatoxin B1 and metabolites to Salmonella typhimurium: structure mutagenicity relationships and mechanisms of action.黄曲霉毒素B1及其代谢产物对鼠伤寒沙门氏菌的直接致突变性：结构-致突变性关系及作用机制
Res Commun Chem Pathol Pharmacol. 1987 Jul;57(1):55-76.
5
Promutagen activation in partially hepatectomized mice.部分肝切除小鼠中的前诱变剂激活
Toxicol Lett. 1982 Dec;14(3-4):253-60. doi: 10.1016/0378-4274(82)90060-1.
6
Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins.某些曲霉和青霉霉菌毒素对鼠伤寒沙门氏菌的致突变性。
Mutat Res. 1978 Nov;58(2-3):193-203. doi: 10.1016/0165-1218(78)90009-5.
7
8
Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of sulphur-containing amino acids.膳食因素对黄曲霉毒素B1致突变性的调节作用：含硫氨基酸的体外效应
Mutat Res. 1989 Apr;222(4):403-7. doi: 10.1016/0165-1218(89)90115-8.
9
Inhibitory effect of phenolic compounds on aflatoxin B1 metabolism and induced mutagenesis.酚类化合物对黄曲霉毒素B1代谢及诱导突变的抑制作用。
Mutat Res. 1987 Apr;177(2):229-39. doi: 10.1016/0027-5107(87)90005-4.
10
Promutagen activation in parasite-infected organisms: preliminary observations with Fasciola hepatica-infected mice and aflatoxin B1.寄生虫感染生物体中的前诱变剂激活：对感染肝片吸虫的小鼠和黄曲霉毒素B1的初步观察
Toxicol Lett. 1981 Jun-Jul;8(4-5):273-82. doi: 10.1016/0378-4274(81)90113-2.
引用本文的文献
1
Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli.属水平分析 PKS-NRPS 和 NRPS-PKS 杂合体揭示了它们在曲霉属中的起源。
BMC Genomics. 2019 Nov 13;20(1):847. doi: 10.1186/s12864-019-6114-2.
2
Evaluation of toxicity of Cercospora piaropi in a mycoherbicide formulation by using bacterial bioluminescence and the Ames mutagenicity tests.利用细菌生物发光和艾姆斯致突变性试验评估梨形尾孢霉菌除草剂制剂的毒性。
Mycopathologia. 2009 Apr;167(4):203-8. doi: 10.1007/s11046-008-9161-9. Epub 2008 Oct 19.
3
Heterokaryosis between Aspergillus oryzae cyclopiazonic acid-defective strains: method for estimating the risk of inducing toxin production among cyclopiazonic acid-defective industrial strains.米曲霉环匹阿尼酸缺陷菌株间的异核体形成：评估环匹阿尼酸缺陷工业菌株中诱导毒素产生风险的方法。
Appl Environ Microbiol. 1985 Oct;50(4):1087-93. doi: 10.1128/aem.50.4.1087-1093.1985.
本文引用的文献
1
ACUTE TOXICITY OF AFLATOXIN B-1 IN RATS.黄曲霉毒素B-1对大鼠的急性毒性
Br J Cancer. 1964 Dec;18(4):756-62. doi: 10.1038/bjc.1964.87.
2
The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling.环匹阿尼酸的分离与结构，环匹青霉（Westling）的一种有毒代谢产物。
Tetrahedron. 1968 Mar;24(5):2101-19. doi: 10.1016/0040-4020(68)88113-x.
3
The acute toxicity of the mycotoxin cyclopiazonic acid to rats.霉菌毒素环匹阿尼酸对大鼠的急性毒性。
Toxicol Appl Pharmacol. 1971 Jan;18(1):114-23. doi: 10.1016/0041-008x(71)90320-6.
4
Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogs.
Cancer Res. 1971 Dec;31(12):1936-42.
5
Aflatoxin mutagenesis.
Mutat Res. 1975;32(1):35-53. doi: 10.1016/0165-1110(75)90010-x.
6
Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.用沙门氏菌/哺乳动物微粒体诱变性试验检测致癌物和诱变剂的方法。
Mutat Res. 1975 Dec;31(6):347-64. doi: 10.1016/0165-1161(75)90046-1.
7
Mycotoxins of Aspergillus oryzae strains for use in the food industry as starters and enzyme producing molds.用于食品工业作为发酵剂和产酶霉菌的米曲霉菌株的霉菌毒素。
Ann Nutr Aliment. 1977;31(4-6):617-24.
8
Cyclopiazonic acid production by Penicillium camemberti Thom and natural occurrence of this mycotoxin in cheese.卡门柏青霉产生的环匹阿尼酸以及这种霉菌毒素在奶酪中的天然存在情况。
Appl Environ Microbiol. 1979 Dec;38(6):1052-5. doi: 10.1128/aem.38.6.1052-1055.1979.
9
Production of cyclopiazonic acid by Aspergillus flavus Link.黄曲霉Link.产生的环匹阿尼酸
Appl Environ Microbiol. 1977 Jan;33(1):211-2. doi: 10.1128/aem.33.1.211-212.1977.
10
Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins.某些曲霉和青霉霉菌毒素对鼠伤寒沙门氏菌的致突变性。
Mutat Res. 1978 Nov;58(2-3):193-203. doi: 10.1016/0165-1218(78)90009-5.
Zotero 插件