De Jong W F, Albrecht M, Bánóczy J, van der Waal I
Int J Oral Surg. 1984 Jun;13(3):221-5. doi: 10.1016/s0300-9785(84)80007-1.
In a combined study of the Free University, Amsterdam and the Semmelweis Medical University, Budapest, the presence of epithelial dysplasia was studied in 100 cases of oral lichen planus. The criteria of epithelial dysplasia which were used in this study correspond with those reported by the WHO Collaborating Centre for Oral Precancerous Lesions in 1978. In approximately 25% of all cases, moderate or at least mild dysplasia was observed. The number of dysplastic changes per section did not show any significant correlation with the clinical type, nor with age or sex. There were no marked differences between the Amsterdam and Budapest material. Long-term data on the follow-up were not available yet. No comment can therefore be given about the meaning of the finding of epithelial dysplasia in lichen planus being a sign of premalignancy or not.
在阿姆斯特丹自由大学和布达佩斯塞梅尔维斯医科大学的一项联合研究中，对100例口腔扁平苔藓患者的上皮发育异常情况进行了研究。本研究中使用的上皮发育异常标准与1978年世界卫生组织口腔癌前病变协作中心报告的标准一致。在所有病例中，约25%观察到中度或至少轻度发育异常。每切片发育异常改变的数量与临床类型、年龄或性别均无显著相关性。阿姆斯特丹和布达佩斯的材料之间没有明显差异。目前尚无长期随访数据。因此，对于扁平苔藓中上皮发育异常的发现是否为癌前病变的标志，无法给出评论。
