Randels P M, Marco L A, Hanspal N S, Robinson B
Hillside J Clin Psychiatry. 1984;6(1):117-21.
Extrapyramidal symptomatology has previously been reported in patients on long-term lithium maintenance. This report emphasizes that, in the presence of organic mental disorder, even brief treatment with lithium may induce severe extrapyramidal signs. Furthermore, toxicity to lithium may occur even though serum lithium levels are at therapeutic levels. Following termination of lithium, symptoms subsided quickly in one patient (five days), but more slowly in the other (16 days). Possible pathophysiology of this phenomenon is discussed.
锥体外系症状此前已有报道见于长期服用锂盐维持治疗的患者。本报告强调，在存在器质性精神障碍的情况下，即使短期使用锂盐治疗也可能诱发严重的锥体外系体征。此外，即使血清锂水平处于治疗范围内，也可能发生锂中毒。停用锂盐后，一名患者的症状迅速缓解（五天），但另一名患者缓解较慢（十六天）。本文讨论了这一现象可能的病理生理学机制。
