Randels P M, Marco L A, Ford D I, Mitchell R, Scholl M, Plesnarski J
Hillside J Clin Psychiatry. 1984;6(2):139-47.
Ten patients with presumed Alzheimer's disease were entered into a pilot study to evaluate the combined effects of lithium and lecithin on cognitive and behavioral parameters. The loss of patients from the study because of toxic effects of lithium was high (30%), and one patient was dropped because of an intervening illness. Of the six remaining patients who completed the study, only two showed behavioral improvement; none showed improvement on measures of cognitive functioning. The possible mechanisms of action are discussed.
十名疑似患有阿尔茨海默病的患者参与了一项试点研究，以评估锂和卵磷脂对认知及行为参数的综合影响。因锂的毒性作用而退出研究的患者比例很高（30%），还有一名患者因并发疾病而退出。在完成研究的其余六名患者中，只有两名表现出行为改善；在认知功能测量方面均未显示出改善。文中讨论了可能的作用机制。
