McKee J C, Bailey B J
Otolaryngol Head Neck Surg. 1984 Jun;92(3):277-86. doi: 10.1177/019459988409200306.
Mandibular reconstruction has posed significant problems, particularly when dealing with loss of mandibular substance. Various implant substances have been utilized in attempts to repair mandibular defects. These have included metals, synthetic material, and organic substances. All have posed significant problems, particularly with rejection and inability of the implant to develop a stable fusion with the surrounding bone. Recently, calcium sulfate has been successfully used as an implant in frontal sinuses, mastoid cavities, and, in one report, as a mandibular implant. The present study looks at the ability of calcium sulfate to induce osteoneogenesis in canine mandibles with and without the presence of a periosteal covering around the implant. Infection somewhat limited the success of the study, but in those animals without major infections, successful replacement of the calcium sulfate by normal bone occurred both with and without the presence of periosteum.
下颌骨重建一直存在重大问题，尤其是在处理下颌骨骨质缺损时。人们尝试使用各种植入物材料来修复下颌骨缺损，这些材料包括金属、合成材料和有机物质。所有这些材料都带来了重大问题，特别是存在排斥反应以及植入物无法与周围骨骼形成稳定融合的问题。最近，硫酸钙已成功用作额窦、乳突腔的植入物，并且有一份报告称其可作为下颌骨植入物。本研究观察了硫酸钙在有或没有植入物周围骨膜覆盖的犬下颌骨中诱导骨生成的能力。感染在一定程度上限制了研究的成功，但在那些没有严重感染的动物中，无论有无骨膜，硫酸钙都成功地被正常骨替代。
