Shi Bin, Zhou Yi, Wang Yi Ning, Cheng Xiang Rong
Key Laboratory of Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan City, People's Republic of China
Int J Oral Maxillofac Implants. 2007 Jul-Aug;22(4):656-65.
To evaluate the combination of surgical-grade calcium sulfate (SGCS) and platelet-rich plasma (PRP) for alveolar ridge preservation prior to implant placement.
Five mongrel dogs were used as subjects. Four enlarged mandibular extraction sockets, 2 on each side, were created in each dog. According to a split-mouth design, the 2 anterior sockets received either SGCS/PRP (SGCS/PRPant) or were left unfilled, while the 2 posterior sockets received either SGCS/PRP (SGCS/PRPpost) or SGCS. Computerized tomographic (CT) scans were conducted at 1 day and 8 weeks postextraction to detect the change in ridge height. Bone scintigraphy was performed at 2, 4, and 6 weeks to investigate new bone formation activity. At 8 weeks, 1 dog was sacrificed for histologic and histomorphometric study. Meanwhile, implants were placed in the remaining 4 dogs. These 4 dogs were sacrificed after 3 months.
Less ridge resorption was observed in the anterior SGCS/PRP-filled sites compared to unfilled sites (P = .001), while no significant difference was found between the SGCS/PRPpost and SGCS groups (P = .544). Bone scintigraphy showed that sites filled with SGCS/PRP showed significantly higher count/pixel at 2 (P = .028), 4 (P = .009), and 6 weeks (P = .037) than the unfilled sites. Nevertheless, the SGCS/PRPpost group achieved significantly higher values than the SGSC group only at 2 weeks (P = .036). Histomorphometrically, the SGCS/PRPant group showed a significantly higher percentage of bone-implant contact than the unfilled group (P = .024), but no significant difference was detected between the SGCS/PRPpost and SGCS groups (P = .979).
Grafting SGCS/PRP in fresh extraction sockets reduced alveolar ridge resorption and promoted the bone formation in this canine model. The addition of PRP to SGCS resulted in the enhancement of bone regeneration in the early phase of healing.
评估外科级硫酸钙（SGCS）与富血小板血浆（PRP）联合用于种植体植入前牙槽嵴保存的效果。
以5只杂种犬为研究对象。每只犬双侧下颌各制备4个扩大的拔牙窝。采用双侧对照设计，一侧的2个前拔牙窝分别植入SGCS/PRP（SGCS/PRPant）或不进行填充，另一侧的2个后拔牙窝分别植入SGCS/PRP（SGCS/PRPpost）或SGCS。拔牙后1天和8周进行计算机断层扫描（CT），检测牙槽嵴高度变化。在2、4和6周进行骨闪烁显像，研究新骨形成活性。8周时，处死1只犬进行组织学和组织形态计量学研究。同时，在其余4只犬中植入种植体。3个月后处死这4只犬。
与未填充部位相比，前侧SGCS/PRP填充部位的牙槽嵴吸收较少（P = 0.001），而SGCS/PRPpost组与SGCS组之间无显著差异（P = 0.544）。骨闪烁显像显示，在2周（P = 0.028）、4周（P = 0.009）和6周（P = 0.037）时，SGCS/PRP填充部位的计数/像素显著高于未填充部位。然而，SGCS/PRPpost组仅在2周时的值显著高于SGSC组（P = 0.036）。组织形态计量学结果显示，SGCS/PRPant组的骨-种植体接触百分比显著高于未填充组（P = 0.024），但SGCS/PRPpost组与SGCS组之间无显著差异（P = 0.979）。
在本犬类模型中，在新鲜拔牙窝中植入SGCS/PRP可减少牙槽嵴吸收并促进骨形成。在SGCS中添加PRP可增强愈合早期的骨再生。
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