McNair D M, Kahn R J, Frankenthaler L M, Faldetta L L
Psychopharmacology (Berl). 1984;83(2):129-33. doi: 10.1007/BF00429720.
Speed of onset of antidepressant effect was studied in 20 depressed outpatients assigned double-blind to equipotent doses of amoxapine or amitriptyline. In counter-balanced order, each patient had 2 periods of 3 weeks on active agent interspersed with 2 similar periods of placebo control. On daily and weekly self-ratings, amoxapine was found to reduce symptoms significantly more rapidly than amitriptyline. Psychiatrist-ratings were consonant with self-reports.
