Glass R M, Uhlenhuth E H, Hartel F W, Matuzas W, Fischman M W
Arch Gen Psychiatry. 1981 Sep;38(9):1048-51. doi: 10.1001/archpsyc.1981.01780340100012.
A group of moderately depressed, nonpsychotic outpatients had impaired performance on a short-term item-recognition memory task (compared with a group of matched normal controls) without evidence of impaired speed or attention on two simpler tasks. Compared with placebo, treatment with imipramine hydrochloride in a multiple crossover design using three-week treatment periods led to improved performance on the memory task without either clinically apparent improvement in depression or significantly improved performance on the other task rather than a specific impairment of short-term memory, but the data do support the presence of cognitive dysfunction in depression, even in ambulatory patients without substantial impairments of attention or motor functioning. The results also indicate that antidepressant drugs can produce improvement in cognitive function, possibly as a forerunner of clinical improvement.
一组中度抑郁的非精神病门诊患者在一项短期项目识别记忆任务中的表现受损（与一组匹配的正常对照组相比），而在两项更简单的任务中没有速度或注意力受损的迹象。在采用三周治疗期的多重交叉设计中，与安慰剂相比，使用盐酸丙咪嗪治疗可使记忆任务的表现得到改善，而抑郁症并无明显临床改善，另一项任务的表现也无显著改善，并非短期记忆的特定损害，但这些数据确实支持抑郁症存在认知功能障碍，即使是在注意力或运动功能无实质性损害的门诊患者中。结果还表明，抗抑郁药物可改善认知功能，这可能是临床改善的先兆。
