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1
Nitrosamines in bacon: a case study of balancing risks.培根中的亚硝胺:平衡风险的案例研究。
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本文引用的文献

1
Formation of mutagens by sorbic acid-nitrite reaction: effects of reaction conditions on biological activities.山梨酸-亚硝酸盐反应产生诱变剂:反应条件对生物活性的影响
Mutat Res. 1980 Nov;73(1):21-8. doi: 10.1016/0027-5107(80)90132-3.
2
Altered incidences of hepatic and hemopoietic neoplasms in F344 rats fed sodium nitrite.
Carcinogenesis. 1983 Sep;4(9):1189-91. doi: 10.1093/carcin/4.9.1189.
3
N-Nitrosamines: a review of chemical and biological properties and their estimation in foodstuffs.
Adv Food Res. 1976;22:1-71. doi: 10.1016/s0065-2628(08)60336-5.

培根中的亚硝胺:平衡风险的案例研究。

Nitrosamines in bacon: a case study of balancing risks.

作者信息

McCutcheon J W

出版信息

Public Health Rep. 1984 Jul-Aug;99(4):360-4.

PMID:6431483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1424609/
Abstract

Nitrite has been used for centuries to preserve, color, and flavor meat. Today, about 10 billion pounds of cured meat products are produced annually, accounting for some one-tenth of the American food supply. Regulators became concerned about the safety of using nitrite in the early 1960s when studies showed the presence of carcinogenic nitrosamines in cured meat products. In the early 1970s, a study at the Massachusetts Institute of Technology implicated nitrite itself as a carcinogen. As studies have raised concern over the safety of nitrite, regulators have had to weigh the potential risk from cancer against nitrite's proven role in protecting consumers from deadly food poisoning bacteria. Today there is little scientific support for the theory that nitrite is a direct carcinogen. To deal with the nitrosamine problem, the U.S. Department of Agriculture (USDA) lowered the permissible amount of nitrite in cured meats to that level considered necessary for botulism protection. Regulators, however, found it necessary to take additional steps with bacon because nitrosamines were found consistently in fried bacon samples. In addition to lowering the amount of nitrite that could be added to "pumped bacon" (cured by injecting liquid curing agents in the pork belly), USDA required the addition of nitrosamine inhibitors and began an intensive monitoring program in processing plants to ensure that fried bacon did not contain confirmable nitrosamines. The cooperative effort between Government and industry resulted in the virtual elimination of confirmable nitrosamines in pumped bacon by 1980. USDA is continuing its efforts to reduce nitrite in meats wherever possible. It is involved in active research programs in the Federal Government, academia, and industry.

摘要

几个世纪以来,亚硝酸盐一直被用于保存肉类、给肉类上色和调味。如今,每年生产约100亿磅腌制肉制品,约占美国食品供应总量的十分之一。20世纪60年代初,当研究表明腌制肉制品中存在致癌性亚硝胺时,监管机构开始关注亚硝酸盐使用的安全性。20世纪70年代初,麻省理工学院的一项研究表明亚硝酸盐本身就是一种致癌物。随着研究引发了对亚硝酸盐安全性的担忧,监管机构不得不权衡癌症的潜在风险与亚硝酸盐在保护消费者免受致命食物中毒细菌侵害方面已被证实的作用。如今,几乎没有科学依据支持亚硝酸盐是直接致癌物这一理论。为了解决亚硝胺问题,美国农业部(USDA)将腌制肉类中亚硝酸盐的允许使用量降低到了认为对预防肉毒杆菌中毒有必要的水平。然而,监管机构发现有必要对培根采取额外措施,因为在油炸培根样本中一直发现有亚硝胺。除了降低可添加到“注水培根”(通过向猪肚中注入液体腌制剂进行腌制)中的亚硝酸盐量外,美国农业部还要求添加亚硝胺抑制剂,并在加工厂启动了一项强化监测计划,以确保油炸培根不含可确认的亚硝胺。政府与行业之间的合作努力使得到1980年注水培根中可确认的亚硝胺几乎消除。美国农业部正在继续努力尽可能减少肉类中的亚硝酸盐含量。它参与了联邦政府、学术界和行业的积极研究项目。