[Changes in antitumor resistance during chemical carcinogenesis].

Subcutaneous injection of 4 mg DMBA to noninbred rats leads to a considerable decrease in host resistance to cancer, which progresses with tumor growth. The rats with inhibited host resistance to cancer accepted well, at the stage of tumor germ, the DMBA-induced tumors from other animals, permitting them to grow--the phenomenon that was not observed in normal noninbred young rats. At the stage of clinically demonstrable nodules at the sites of DMBA injections, the tumors with different transplantability did not only get adapted but developed distant metastases in part of the animals.