正常肾功能患者因碳酸酐酶抑制剂和水杨酸盐引起的代谢性酸中毒。
Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function.
作者信息
Cowan R A, Hartnell G G, Lowdell C P, Baird I M, Leak A M
出版信息
Br Med J (Clin Res Ed). 1984 Aug 11;289(6441):347-8. doi: 10.1136/bmj.289.6441.347.
Abstract
Two young patients with unimpaired renal and hepatic function were found to have developed metabolic acidosis after treatment for glaucoma and joint pain with a combination of salicylates and carbonic anhydrase inhibitors in normal doses. Carbonic anhydrase inhibitors appear to interact with salicylates to produce serious metabolic acidosis in patients without the predisposing factors generally considered to constitute risks. It is recommended that treatment combining salicylates and carbonic anhydrase inhibitors is either kept to a minimum or avoided.
摘要
两名肾功能和肝功能未受损的年轻患者在使用正常剂量的水杨酸盐和碳酸酐酶抑制剂联合治疗青光眼和关节疼痛后，出现了代谢性酸中毒。碳酸酐酶抑制剂似乎与水杨酸盐相互作用，在没有通常被认为构成风险的易感因素的患者中产生严重的代谢性酸中毒。建议将水杨酸盐和碳酸酐酶抑制剂的联合治疗保持在最低限度或避免使用。
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