Duprat G, Chalaoui J, Sylvestre J, Simard P, Roy P, Potvin C, Cantin J, Robidoux A
Can J Surg. 1984 Jan;27(1):57-9.
Chemotherapy by intra-arterial infusion, using mitomycin C and 5-fluorouracil, was administered to six patients with cancer of the rectum. In three patients who presented initially with an inoperable rectal tumour, medication was infused through the inferior mesenteric artery. Tumour regression was documented in all three, allowing subsequent resection in two. Of three other patients with locally recurrent rectal cancer, none showed tumour regression after infusion, but two experienced substantial relief of perineal pain, with improvement in the quality of life. Unexpected complications occurred in the form of a reversible ischemic colitis in two patients and an arterioenteric fistula in a third.
对6例直肠癌患者采用丝裂霉素C和5-氟尿嘧啶经动脉内灌注进行化疗。3例最初表现为无法手术切除的直肠肿瘤患者，通过肠系膜下动脉进行药物灌注。所有3例均记录到肿瘤缩小，其中2例随后得以进行手术切除。另外3例局部复发性直肠癌患者，灌注后均未出现肿瘤缩小，但2例患者会阴部疼痛明显缓解，生活质量得到改善。出现了意想不到的并发症，2例患者发生可逆性缺血性结肠炎，1例患者发生动脉肠瘘。
