Yoshikawa T, Tanaka H, Kondo M
J Appl Biochem. 1983 Dec;5(6):382-7.
Adjuvant arthritis was induced in rats by the injection of Mycobacterium tuberculosis, and its severity was scored according to the macroscopic findings of the legs, tails, and ears. The average score so obtained was lower when the rats also received indomethacin (1.5 mg/kg/day). The depression of the albumin/globulin ratio was inhibited significantly by the administration of indomethacin. The levels of acid phosphatase and beta-glucuronidase were elevated after the injection of an adjuvant, but they decreased to some extent in rats administered indomethacin. The levels of thiobarbituric acid (TBA)-reactive substances in the sera and synovia were elevated at 2 weeks after the injection of adjuvant and decreased thereafter. In rats administered 1.5 mg/kg of indomethacin, the increase in both serum and synovial levels of TBA reactants was inhibited significantly. These observations suggest that the aggravation of adjuvant arthritis may be associated with lipid peroxidation and that indomethacin may, in part, exert its anti-inflammatory effect by preventing lipid peroxide-induced damage of the synovial membrane.
通过注射结核分枝杆菌在大鼠中诱发佐剂性关节炎，并根据腿部、尾巴和耳朵的宏观表现对其严重程度进行评分。当大鼠同时接受吲哚美辛（1.5毫克/千克/天）时，如此获得的平均评分较低。吲哚美辛的给药显著抑制了白蛋白/球蛋白比值的降低。注射佐剂后酸性磷酸酶和β-葡萄糖醛酸酶水平升高，但在给予吲哚美辛的大鼠中它们在一定程度上下降。注射佐剂后2周血清和滑膜中硫代巴比妥酸（TBA）反应性物质水平升高，此后下降。在给予1.5毫克/千克吲哚美辛的大鼠中，血清和滑膜中TBA反应物水平的升高均受到显著抑制。这些观察结果表明佐剂性关节炎的加重可能与脂质过氧化有关，并且吲哚美辛可能部分地通过防止脂质过氧化物诱导的滑膜损伤发挥其抗炎作用。
