Transgrow与Gonozyme在邮寄标本中检测淋病奈瑟菌的比较。
Comparison of Transgrow and Gonozyme for the detection of Neisseria gonorrhoeae in mailed specimens.
作者信息
Martin R, Wentworth B B, Coopes S, Larson E H
出版信息
J Clin Microbiol. 1984 Jun;19(6):893-5. doi: 10.1128/jcm.19.6.893-895.1984.
The Transgrow culture system and Gonozyme (Abbott Laboratories, North Chicago, Ill.), an enzyme-linked immunosorbent assay procedure, were compared by examining 510 patients (320 females, 190 males) from whom duplicate genital swabs were obtained for the diagnosis of Neisseria gonorrhoeae infection. Both Transgrow and the Gonozyme swabs were mailed to the laboratory. Clinical, epidemiological, and laboratory data for the 30 specimens for which there were discrepancies were evaluated to determine the probability of gonorrhea. At the same time, Gonozyme was compared to on-site Thayer-Martin cultures from 258 of the 510 patients, with a 93% agreement. When sensitivity and specificity were calculated on the basis of clinical, epidemiological, and on-site laboratory data, Gonozyme had a sensitivity of 95% and a specificity of 99%. Transgrow culture was considered to have a 100% specificity and a sensitivity of 69%. Gonozyme appeared to be a superior method for the diagnosis of gonorrhea by means of mailed specimens.
通过对510例患者（320例女性，190例男性）进行检测，比较了Transgrow培养系统和酶联免疫吸附测定法Gonozyme（雅培实验室，伊利诺伊州北芝加哥），这些患者均采集了两份生殖器拭子用于淋病奈瑟菌感染的诊断。Transgrow拭子和Gonozyme拭子均邮寄至实验室。对30份存在差异的标本的临床、流行病学和实验室数据进行评估，以确定淋病的可能性。同时，将Gonozyme与510例患者中258例患者的现场瑟-马二氏培养基培养结果进行比较，一致性为93%。根据临床、流行病学和现场实验室数据计算敏感性和特异性时，Gonozyme的敏感性为95%，特异性为99%。Transgrow培养法的特异性被认为是100%，敏感性为69%。对于通过邮寄标本诊断淋病，Gonozyme似乎是一种更优的方法。
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