Katakami H, Kato Y, Inada M, Imura H
J Endocrinol Invest. 1984 Jun;7(3):231-3. doi: 10.1007/BF03348429.
Cold intolerance and secondary amenorrhea developed in a patient who had meningoencephalitis 4 yr prior to study. A clinical diagnosis of hypothalamic hypothyroidism was made on the basis of low serum thyroxine and triiodothyronine levels, and low plasma thyrotropin concentrations, which were responsive to thyrotropin-releasing hormone (TRH). The secretion of the remaining pituitary hormones (growth hormone, prolactin, adrenocorticotropin and gonadotropins) was intact. Not only was thyroid function normalized by oral administration of TRH, but also menses resumed after adequate replacement therapy with thyroid hormone. These results imply that hypothyroidism in this patient was due to isolated dysfunction of hypothalamic TRH release.
在本研究前4年患脑膜脑炎的一名患者出现了不耐寒和继发性闭经。根据血清甲状腺素和三碘甲状腺原氨酸水平降低以及血浆促甲状腺素浓度降低（这些指标对促甲状腺激素释放激素（TRH）有反应），做出了下丘脑性甲状腺功能减退的临床诊断。其余垂体激素（生长激素、催乳素、促肾上腺皮质激素和促性腺激素）的分泌完好。口服TRH不仅使甲状腺功能恢复正常，而且在用甲状腺激素进行充分替代治疗后月经也恢复了。这些结果表明该患者的甲状腺功能减退是由于下丘脑TRH释放的孤立性功能障碍所致。
