苯妥英在体外短期试验中无致突变性。
Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests.
作者信息
Léonard A, de Meester C, Fabry L, de Saint-Georges L, Dumont P
出版信息
Mutat Res. 1984 Aug-Sep;137(2-3):79-88. doi: 10.1016/0165-1218(84)90095-8.
PMID:6433192
Abstract
The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.
摘要
已通过使用鼠伤寒沙门氏菌的艾姆斯试验重新评估了苯妥英（DPH）及其主要代谢物5-（对羟基苯基）-5-苯基乙内酰脲（HPPH）的致突变性，并且仅针对DPH，通过用人淋巴细胞进行的体外细胞遗传学试验和微管蛋白聚合的比浊法进行了评估。由于在此使用的所有测试系统中均获得阴性结果，因此必须得出结论，DPH没有致突变特性。
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