Mas M, Gonzalez M C, Rodriguez M, Castro R, Oaknin S
Neuroendocrinology. 1984 Aug;39(2):156-61. doi: 10.1159/000123972.
In order to investigate the relative contribution of the serotoninergic and catecholaminergic innervation of different brain structures to the control of gonadotropin secretion in the male, adult rats were given bilateral injections of the selective neurotoxins, 5,7-dihydroxytryptamine and 6-hydroxydopamine, into the mediobasal hypothalamus, the medial preoptic area, the amygdala, and the medial forebrain bundle. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone, testosterone, pituitary follicle-stimulating hormone, and LH content were measured 15 days later. The medial preoptic area 5,7-dihydroxytryptamine injections were followed by 2- to 3-fold increases of serum LH and testosterone levels and pituitary LH concentration. The 6-hydroxydopamine injections in the medial forebrain bundle resulted in a 60% decrease of pituitary LH content, associated with serum levels of LH and testosterone which were lowered, although not significantly. None of the treatments seemed to influence either serum or pituitary concentrations of follicle-stimulating hormone. These results suggest a hitherto undocumented major function of the serotoninergic innervation of the medial preoptic area in the control of LH secretion in the male and confirm previous reports indicating that some of the catecholaminergic fibers carried by the medial forebrain bundle can be modulatory for LH secretion.
为了研究不同脑结构的5-羟色胺能和儿茶酚胺能神经支配对雄性动物促性腺激素分泌控制的相对贡献，对成年大鼠的中基底下丘脑、内侧视前区、杏仁核和内侧前脑束进行双侧注射选择性神经毒素5,7-二羟色胺和6-羟基多巴胺。15天后测量血清促黄体生成素（LH）、促卵泡激素、睾酮、垂体促卵泡激素水平以及LH含量。在内侧视前区注射5,7-二羟色胺后，血清LH和睾酮水平以及垂体LH浓度增加了2至3倍。在内侧前脑束注射6-羟基多巴胺导致垂体LH含量降低60%，同时血清LH和睾酮水平降低，尽管降低幅度不显著。所有处理似乎均未影响血清或垂体促卵泡激素的浓度。这些结果表明，内侧视前区的5-羟色胺能神经支配在雄性动物LH分泌控制中具有迄今未被记录的主要功能，并证实了先前的报道，即内侧前脑束携带的一些儿茶酚胺能纤维可调节LH分泌。
