Pascali E, Pezzoli A
Acta Haematol. 1986;75(4):193-8. doi: 10.1159/000206123.
62 consecutive patients with newly diagnosed malignant non-Hodgkin's lymphoma (NHL) were investigated for the presence, type, and amount of serum and urine monoclonal immunoglobulin abnormalities. The overall incidence of monoclonal gammopathy (MG) was 81%. M components of the IgM and IgG classes were found in the serum of 52% of the patients. Their concentration was below 10 g/l in 54% of cases and above 20 g/l in 26% of cases. The highest incidence of serum M components (75%) was seen in plasmacytoid lymphocytic lymphoma (PLL) and the lowest (38%) in follicular center cell lymphoma. A monoclonal free light chain, i.e., Bence Jones protein (BJP), was documented in the urine of 61% of cases with a daily excretion comprised between 0.01 and 9.24 g. The isolated urinary excretion of BJP was a major finding accounting for 36% of all MG found in association with NHL. It occurred in all histopathological subtypes with a frequency ranging from 17% of PLL to 37% of small lymphocytic lymphoma.
对62例新诊断的恶性非霍奇金淋巴瘤（NHL）患者进行了血清和尿液单克隆免疫球蛋白异常的存在情况、类型及含量的调查。单克隆丙种球蛋白病（MG）的总体发生率为81%。52%的患者血清中发现了IgM和IgG类的M成分。其中54%的病例其浓度低于10g/L，26%的病例高于20g/L。血清M成分发生率最高的是浆细胞样淋巴细胞淋巴瘤（PLL）（75%），最低的是滤泡中心细胞淋巴瘤（38%）。61%的病例尿液中检测到单克隆游离轻链，即本周蛋白（BJP），每日排泄量在0.01至9.24g之间。孤立性尿液BJP排泄是一项主要发现，占与NHL相关的所有MG的36%。它出现在所有组织病理学亚型中，发生率从PLL的17%到小淋巴细胞淋巴瘤的37%不等。
