Sinclair D, Dagg J H, Mowat A M, Parrott D M, Stott D I
J Clin Pathol. 1984 Apr;37(4):463-6. doi: 10.1136/jcp.37.4.463.
The presence of paraproteins in the sera of 10 patients with chronic lymphocytic leukaemia (CLL) was investigated using immunoisoelectric focusing. Monoclonal immunoglobulins were found in nine of these 10 sera. Five sera contained a single monoclonal IgM paraprotein, one serum contained a single monoclonal IgG paraprotein, while three sera contained more than one monoclonal paraprotein--namely, IgM + IgD, IgM + IgG, and IgM + IgD + IgG. The results indicate that the malignant B cells of CLL may be at a later stage of differentiation than previously assumed and serum monoclonal immunoglobulin could be of value as a tumour marker.
运用免疫等电聚焦技术对10例慢性淋巴细胞白血病（CLL）患者血清中的副蛋白进行了研究。在这10份血清中，有9份发现了单克隆免疫球蛋白。5份血清含有单一的单克隆IgM副蛋白，1份血清含有单一的单克隆IgG副蛋白，而3份血清含有不止一种单克隆副蛋白，即IgM + IgD、IgM + IgG以及IgM + IgD + IgG。结果表明，CLL的恶性B细胞可能处于比先前设想的更晚期的分化阶段，血清单克隆免疫球蛋白可作为一种肿瘤标志物。
