Huang B S, Unni K K, Payne W S
Ann Thorac Surg. 1984 Sep;38(3):207-10. doi: 10.1016/s0003-4975(10)62238-2.
The incidence of cancer in a pharyngoesophageal (Zenker's) diverticulum was 0.4% among 1,249 patients treated for such diverticula at the Mayo Clinic in a 53-year period. Twenty-four patients with squamous cell carcinoma arising in a pharyngoesophageal diverticulum have been reported by others. However, most of the patients died of the malignancy within 2 years of treatment, and there were no long-term survivors. We describe 2 long-term survivors who were without evidence of tumor or diverticulum recurrence 4 1/4 and 8 years after one-stage pharyngoesophageal diverticulectomy. Review of the literature revealed that most patients with cancer in pharyngoesophageal diverticulum should be managed in a manner similar to that for patients with ordinary cervical esophageal malignancy. However, our data suggest that when the tumor is well localized without full-thickness penetration, nodal metastasis, or extension to the line of resection (as in the 2 patients discussed), diverticulectomy alone can provide satisfactory control of cancer with minimal therapeutic risk.
在梅奥诊所53年期间接受治疗的1249例咽食管（Zenker氏）憩室患者中，癌症发生率为0.4%。其他人曾报告过24例咽食管憩室发生鳞状细胞癌的患者。然而，大多数患者在治疗后2年内死于恶性肿瘤，没有长期存活者。我们描述了2例长期存活者，他们在一期咽食管憩室切除术后4又1/4年和8年没有肿瘤或憩室复发的迹象。文献回顾显示，大多数咽食管憩室癌患者的治疗方式应与普通颈段食管癌患者相似。然而，我们的数据表明，当肿瘤定位良好，没有全层穿透、淋巴结转移或延伸至切除线时（如所讨论的2例患者），单独进行憩室切除术可以以最小的治疗风险提供对癌症的满意控制。
