Simmons M A, Jones M D, Battaglia F C, Meschia G
Pediatr Res. 1978 Feb;12(2):90-2. doi: 10.1203/00006450-197802000-00004.
Insulin infused into a sheep fetus over a 3-hr period at the rate of approximately 0.24 U.kg-1.h-1 increased fetal glucose uptake (utilization) from 4.4 +/- 0.7 mg.min-1.kg-1 to 6.9 +/- 0.9 mg.min-1.kg-1 as compared to a noninsulin control period. Insulin administration did not alter fetal oxygen consumption (8.6 +/- 0.7 ml.min-1.kg-1 vs. 7.7 +/- 0.7 ml.min-1.kg-1), umbilical blood flow (220 +/- 1 ml.min-1.kg-1 vs. 209 +/- 16 ml.min-1.kg-1), or the placental clearances of antipyrine (114 +/- 7 ml.min-1.kg-1 vs. 109 +/- 8ml.min-1.kg-1) and urea (24.5 +/- 2.2 ml.min-1.kg-1 vs. 25.0 +/- 2.1 ml.min-1.kg-1). Fetal plasma glucose concentration fell significantly (0.22 +/- 0.01 mg.ml-1 to 0.16 +/- 0.01 mg.ml-1) during insulin infusion. The insulin effect on fetal glucose uptake occurred over a range of maternal glucose concentrations (0.32 leads to 0.78 mg.ml-1), which were not altered by the infusion of insulin in the fetal compartment. Insulin has a specific effect on increasing fetal glucose uptake and utilization.
在3小时内以约0.24 U·kg⁻¹·h⁻¹的速率向绵羊胎儿输注胰岛素，与非胰岛素对照期相比，胎儿葡萄糖摄取（利用）从4.4±0.7 mg·min⁻¹·kg⁻¹增加到6.9±0.9 mg·min⁻¹·kg⁻¹。给予胰岛素并未改变胎儿的耗氧量（8.6±0.7 ml·min⁻¹·kg⁻¹对7.7±0.7 ml·min⁻¹·kg⁻¹）、脐血流量（220±1 ml·min⁻¹·kg⁻¹对209±16 ml·min⁻¹·kg⁻¹），或安替比林（114±7 ml·min⁻¹·kg⁻¹对109±8 ml·min⁻¹·kg⁻¹）和尿素（24.5±2.2 ml·min⁻¹·kg⁻¹对25.0±2.1 ml·min⁻¹·kg⁻¹）的胎盘清除率。在胰岛素输注期间，胎儿血浆葡萄糖浓度显著下降（从0.22±0.01 mg·ml⁻¹降至0.16±0.01 mg·ml⁻¹）。胰岛素对胎儿葡萄糖摄取的作用发生在一系列母体葡萄糖浓度范围内（0.32至0.78 mg·ml⁻¹），而胎儿体内输注胰岛素并未改变这些浓度。胰岛素对增加胎儿葡萄糖摄取和利用具有特定作用。
