对雄甾酮具有高和低肝微粒体UDP-葡萄糖醛酸基转移酶活性的Wistar大鼠的分类及基因表达
Classification and genetic expression of Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone.
作者信息
Matsui M, Watanabe H K
出版信息
Biochem J. 1982 Jan 15;202(1):171-4. doi: 10.1042/bj2020171.
Abstract
Male and female Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone were classified by partial hepatectomy. The breeding experiments between the classified high-activity and low-activity rats show that the genetic expression of the high transferase activity is inherited in an autosomal dominant fashion.
摘要
通过部分肝切除术对雄性和雌性Wistar大鼠进行分类，这些大鼠对雄甾酮具有高和低的肝微粒体UDP-葡萄糖醛酸基转移酶活性。对分类后的高活性和低活性大鼠进行的繁殖实验表明，高转移酶活性的基因表达以常染色体显性方式遗传。
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本文引用的文献
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Hepatic UDP-glucuronyltransferase in Wistar and Gunn rats--in vitro activation by diethylnitrosamine.Wistar大鼠和Gunn大鼠肝脏中的UDP-葡萄糖醛酸转移酶——二乙基亚硝胺的体外激活作用
Biochem Biophys Res Commun. 1968 Sep 6;32(5):866-72. doi: 10.1016/0006-291x(68)90321-5.
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Kinetic properties of microsomal UDP-glucuronyltransferase. Evidence for cooperative kinetics and activation by UDP-N-acetylglucosamine.微粒体UDP-葡萄糖醛酸基转移酶的动力学特性。协同动力学及UDP-N-乙酰葡糖胺激活作用的证据。
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