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对雄甾酮具有高和低肝微粒体UDP-葡萄糖醛酸基转移酶活性的Wistar大鼠的分类及基因表达

Classification and genetic expression of Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone.

作者信息

Matsui M, Watanabe H K

出版信息

Biochem J. 1982 Jan 15;202(1):171-4. doi: 10.1042/bj2020171.

DOI:10.1042/bj2020171
PMID:6805467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1158087/
Abstract

Male and female Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone were classified by partial hepatectomy. The breeding experiments between the classified high-activity and low-activity rats show that the genetic expression of the high transferase activity is inherited in an autosomal dominant fashion.

摘要

通过部分肝切除术对雄性和雌性Wistar大鼠进行分类，这些大鼠对雄甾酮具有高和低的肝微粒体UDP-葡萄糖醛酸基转移酶活性。对分类后的高活性和低活性大鼠进行的繁殖实验表明，高转移酶活性的基因表达以常染色体显性方式遗传。

相似文献

1
Classification and genetic expression of Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone.对雄甾酮具有高和低肝微粒体UDP-葡萄糖醛酸基转移酶活性的Wistar大鼠的分类及基因表达
Biochem J. 1982 Jan 15;202(1):171-4. doi: 10.1042/bj2020171.
2
Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein.Wistar大鼠中雄甾酮UDP-葡萄糖醛酸基转移酶活性的遗传缺陷是由于酶蛋白的缺失。
Biochem J. 1986 Feb 15;234(1):139-44. doi: 10.1042/bj2340139.
3
Developmental alteration of hepatic UDP-glucuronosyltransferase and sulphotransferase towards androsterone and 4-nitrophenol in Wistar rats.Wistar大鼠肝脏中尿苷二磷酸葡萄糖醛酸基转移酶和磺基转移酶对雄甾酮和4-硝基苯酚的发育性变化
Biochem J. 1982 May 15;204(2):441-7. doi: 10.1042/bj2040441.
4
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.纯化大鼠肝脏3α-羟基类固醇UDP-葡萄糖醛酸基转移酶的品系差异。
Biochem J. 1985 Sep 1;230(2):403-9. doi: 10.1042/bj2300403.
5
Strain differences in rat liver (UDP-glucuronyltransferase activity towards androsterone.大鼠肝脏中（尿苷二磷酸葡萄糖醛酸基转移酶对雄甾酮的活性）的品系差异。
Biochem J. 1979 Jun 1;179(3):483-7. doi: 10.1042/bj1790483.
6
Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats.类固醇激素和外源性化学物质对Wistar大鼠中针对雄甾酮和4-硝基苯酚的UDP-葡萄糖醛酸基转移酶活性青春期发育的影响。
Biochem J. 1984 Sep 1;222(2):321-6. doi: 10.1042/bj2220321.
7
Enhancement of intestinal UDP-glucuronosyltranferase activity in partially hepatectomized rats.部分肝切除大鼠肠道UDP-葡萄糖醛酸转移酶活性的增强
Biochim Biophys Acta. 1998 May 8;1380(3):345-53. doi: 10.1016/s0304-4165(98)00003-8.
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The molecular basis of the inherited deficiency of androsterone UDP-glucuronyltransferase in Wistar rats.Wistar大鼠中雄甾酮UDP-葡萄糖醛酸基转移酶遗传性缺乏的分子基础。
FEBS Lett. 1987 Mar 23;213(2):448-52. doi: 10.1016/0014-5793(87)81540-5.
9
Studies on the genetic linkage of bilirubin and androsterone UDP-glucuronyltransferases by cross-breeding of two mutant rat strains.通过两种突变大鼠品系的杂交对胆红素和雄甾酮UDP-葡萄糖醛酸基转移酶的遗传连锁研究。
Biochem J. 1988 Jun 15;252(3):897-900. doi: 10.1042/bj2520897.
10
Discontinuous variation in hepatic uridine diphosphate glucuronyltransferase toward androsterone in Wistar rats. A regulatory factor for in vivo metabolism of androsterone.Wistar大鼠肝脏中尿苷二磷酸葡萄糖醛酸基转移酶对雄酮的不连续变异。雄酮体内代谢的一种调节因子。
Biochem Pharmacol. 1979;28(3):411-5. doi: 10.1016/0006-2952(79)90107-2.

引用本文的文献

1
Developmental alteration of hepatic UDP-glucuronosyltransferase and sulphotransferase towards androsterone and 4-nitrophenol in Wistar rats.Wistar大鼠肝脏中尿苷二磷酸葡萄糖醛酸基转移酶和磺基转移酶对雄甾酮和4-硝基苯酚的发育性变化
Biochem J. 1982 May 15;204(2):441-7. doi: 10.1042/bj2040441.
2
Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats.类固醇激素和外源性化学物质对Wistar大鼠中针对雄甾酮和4-硝基苯酚的UDP-葡萄糖醛酸基转移酶活性青春期发育的影响。
Biochem J. 1984 Sep 1;222(2):321-6. doi: 10.1042/bj2220321.
3
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.纯化大鼠肝脏3α-羟基类固醇UDP-葡萄糖醛酸基转移酶的品系差异。
Biochem J. 1985 Sep 1;230(2):403-9. doi: 10.1042/bj2300403.
4
Studies on the genetic linkage of bilirubin and androsterone UDP-glucuronyltransferases by cross-breeding of two mutant rat strains.通过两种突变大鼠品系的杂交对胆红素和雄甾酮UDP-葡萄糖醛酸基转移酶的遗传连锁研究。
Biochem J. 1988 Jun 15;252(3):897-900. doi: 10.1042/bj2520897.
5
Isolation of multiple normal and functionally defective forms of uridine diphosphate-glucuronosyltransferase from inbred Gunn rats.从近交系Gunn大鼠中分离出多种正常及功能缺陷型尿苷二磷酸葡萄糖醛酸基转移酶。
J Clin Invest. 1987 Feb;79(2):327-34. doi: 10.1172/JCI112816.
6
Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein.Wistar大鼠中雄甾酮UDP-葡萄糖醛酸基转移酶活性的遗传缺陷是由于酶蛋白的缺失。
Biochem J. 1986 Feb 15;234(1):139-44. doi: 10.1042/bj2340139.

本文引用的文献

1
Hepatic UDP-glucuronyltransferase in Wistar and Gunn rats--in vitro activation by diethylnitrosamine.Wistar大鼠和Gunn大鼠肝脏中的UDP-葡萄糖醛酸转移酶——二乙基亚硝胺的体外激活作用
Biochem Biophys Res Commun. 1968 Sep 6;32(5):866-72. doi: 10.1016/0006-291x(68)90321-5.
2
UDP-glucuronyltransferase in perfused rat liver and in microsomes: influence of phenobarbital and 3-methylcholanthrene.灌注大鼠肝脏和微粒体中的UDP-葡萄糖醛酸基转移酶：苯巴比妥和3-甲基胆蒽的影响
Eur J Biochem. 1974 Aug 1;46(3):451-9.
3
Kinetic properties of microsomal UDP-glucuronyltransferase. Evidence for cooperative kinetics and activation by UDP-N-acetylglucosamine.微粒体UDP-葡萄糖醛酸基转移酶的动力学特性。协同动力学及UDP-N-乙酰葡糖胺激活作用的证据。
Biochim Biophys Acta. 1973 May 5;309(1):58-66. doi: 10.1016/0005-2744(73)90317-3.
4
Variations in biliary metabolites of androsterone in female rats.雌性大鼠中雄酮胆汁代谢产物的变化
J Steroid Biochem. 1977 Apr;8(4):319-22. doi: 10.1016/0022-4731(77)90027-9.
5
An improved assay for steroid glucuronyltransferase in rat liver microsomes.大鼠肝微粒体中类固醇葡萄糖醛酸转移酶的一种改良测定法。
Anal Biochem. 1976 Jul;74(1):35-40. doi: 10.1016/0003-2697(76)90307-9.
6
Variability of androsterone metabolism in male Wistar rats.雄性Wistar大鼠雄甾酮代谢的变异性
Biochem Pharmacol. 1979 Apr 1;28(7):1023-8. doi: 10.1016/0006-2952(79)90298-3.
7
Reactivation of a pure defective UDP-glucuronyltransferase from homozygous Gunn rat liver.纯合子Gunn大鼠肝脏中纯合缺陷型UDP-葡萄糖醛酸基转移酶的重新激活。
FEBS Lett. 1978 Mar 15;87(2):207-11. doi: 10.1016/0014-5793(78)80333-0.
8
Strain differences in rat liver (UDP-glucuronyltransferase activity towards androsterone.大鼠肝脏中（尿苷二磷酸葡萄糖醛酸基转移酶对雄甾酮的活性）的品系差异。
Biochem J. 1979 Jun 1;179(3):483-7. doi: 10.1042/bj1790483.
9
Stimulation of defective Gunn-rat liver uridine diphosphate glucuronyltransferase activity in vitro by alkyl ketones.烷基酮对体外培养的缺陷型冈恩大鼠肝脏尿苷二磷酸葡萄糖醛酸基转移酶活性的刺激作用。
Biochem J. 1979 Mar 1;177(3):993-5. doi: 10.1042/bj1770993.
10
Discontinuous variation in hepatic uridine diphosphate glucuronyltransferase toward androsterone in Wistar rats. A regulatory factor for in vivo metabolism of androsterone.Wistar大鼠肝脏中尿苷二磷酸葡萄糖醛酸基转移酶对雄酮的不连续变异。雄酮体内代谢的一种调节因子。
Biochem Pharmacol. 1979;28(3):411-5. doi: 10.1016/0006-2952(79)90107-2.