Canepa-Anson R, Williams M, Marshall J, Mitsuoka T, Lightman S, Sutton R
Br Med J (Clin Res Ed). 1984 Oct 6;289(6449):866-8. doi: 10.1136/bmj.289.6449.866.
A woman with tachycardia associated with polyuria was investigated. Electrophysiological analysis showed that the tachycardia was an atrioventricular nodal re-entrant tachycardia. Programmed stimulation was then used to provoke and sustain the tachycardia for 40 minutes. Polyuria, with an appreciable increase in free water clearance, was observed. This was associated with reduction in plasma and urinary arginine vasopressin concentrations. Appreciable natriuresis also developed. These results support the hypothesis that the polyuria with increased free water clearance and the natriuresis occurring during sustained tachycardia in man are due to inhibition of secretion of vasopressin and the release of natriuretic factor.
对一名伴有多尿的心动过速女性进行了检查。电生理分析显示，该心动过速为房室结折返性心动过速。然后采用程序刺激诱发并维持心动过速40分钟。观察到多尿，自由水清除率明显增加。这与血浆和尿中精氨酸血管加压素浓度降低有关。还出现了明显的利钠作用。这些结果支持这样的假说，即人类持续性心动过速期间出现的自由水清除率增加的多尿和利钠作用是由于血管加压素分泌受抑制和利钠因子释放所致。
