具有杀菌活性的苯并咪唑新杂环衍生物。X - 5 - 氟 - 2 -（5'-硝基 - 2'-呋喃基） - 苯并咪唑（F - O - NO₂）的体内毒性；初步观察
New heterocyclic derivatives of benzimidazole with germicidal activity. X-In vivo toxicity of 5-fluoro-2-(5'-nitro-2'-furyl)-benzimidazole (F-O-NO2); preliminary observations.
作者信息
Pedini M, De Meo G, Ricci A, Tassi C, Bastianini L
机构信息
Istituto di Biochimica e Chimica Medica, Università degli Studi di Perugia, Italia.
出版信息
Farmaco. 1994 Apr;49(4):303-4.
PMID:8049013
Abstract
The in vivo toxicity of 5-fluoro-2-(5'-nitro-2'-furyl) benzimidazole vehiculated in liposomes (L-FONO2), induced in mice by intraperitoneal injection, was evaluated. Toxicity was tested looking at the liver and kidney damage by determining some specific functional parameters (seric urea, seric GPT and urinary beta-NAG): no modifications were observed after administration of L-FONO2 for seven days.
摘要
评估了通过腹腔注射给小鼠注射载于脂质体中的5-氟-2-(5'-硝基-2'-呋喃基)苯并咪唑（L-FONO2）的体内毒性。通过测定一些特定的功能参数（血清尿素、血清谷丙转氨酶和尿β-N-乙酰氨基葡萄糖苷酶）来检测肝脏和肾脏损伤以测试毒性：在给予L-FONO2七天后未观察到任何变化。
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