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淋病奈瑟菌的诱变：缺乏易错修复。

Mutagenesis of Neisseria gonorrhoeae: absence of error-prone repair.

作者信息

Campbell L A, Yasbin R E

出版信息

J Bacteriol. 1984 Oct;160(1):288-93. doi: 10.1128/jb.160.1.288-293.1984.

DOI:10.1128/jb.160.1.288-293.1984
PMID:6434520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC214714/
Abstract

The lethal and mutagenic effects of various mutagens on Neisseria gonorrhoeae were investigated. Lethality studies demonstrated that N. gonorrhoeae was relatively sensitive to ethyl methanesulfonate, UV light, and methyl methanesulfonate. Although N. gonorrhoeae was readily mutated by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine for the three genetic markers assayed, no increase in the mutation frequency was observed for any of the selective markers after UV irradiation or methyl methanesulfonate treatment. These results suggest that N. gonorrhoeae lacks an error-prone repair mechanism.

摘要

研究了各种诱变剂对淋病奈瑟菌的致死和诱变作用。致死性研究表明，淋病奈瑟菌对甲磺酸乙酯、紫外线和甲磺酸甲酯相对敏感。虽然对于所检测的三个遗传标记，淋病奈瑟菌很容易被甲磺酸乙酯和N-甲基-N'-硝基-N-亚硝基胍诱变，但在紫外线照射或甲磺酸甲酯处理后，任何选择标记的突变频率均未增加。这些结果表明淋病奈瑟菌缺乏易错修复机制。

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