淋病奈瑟菌的诱变：缺乏易错修复。
Mutagenesis of Neisseria gonorrhoeae: absence of error-prone repair.
作者信息
Campbell L A, Yasbin R E
出版信息
J Bacteriol. 1984 Oct;160(1):288-93. doi: 10.1128/jb.160.1.288-293.1984.
Abstract
The lethal and mutagenic effects of various mutagens on Neisseria gonorrhoeae were investigated. Lethality studies demonstrated that N. gonorrhoeae was relatively sensitive to ethyl methanesulfonate, UV light, and methyl methanesulfonate. Although N. gonorrhoeae was readily mutated by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine for the three genetic markers assayed, no increase in the mutation frequency was observed for any of the selective markers after UV irradiation or methyl methanesulfonate treatment. These results suggest that N. gonorrhoeae lacks an error-prone repair mechanism.
摘要
研究了各种诱变剂对淋病奈瑟菌的致死和诱变作用。致死性研究表明，淋病奈瑟菌对甲磺酸乙酯、紫外线和甲磺酸甲酯相对敏感。虽然对于所检测的三个遗传标记，淋病奈瑟菌很容易被甲磺酸乙酯和N-甲基-N'-硝基-N-亚硝基胍诱变，但在紫外线照射或甲磺酸甲酯处理后，任何选择标记的突变频率均未增加。这些结果表明淋病奈瑟菌缺乏易错修复机制。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 1958 Oct 15;44(10):1072-8. doi: 10.1073/pnas.44.10.1072.
2
CORRELATION BETWEEN GENETIC TRANSFORMABILITY AND NON-PHOTOREACTIVABILITY IN BACILLUS SUBTILIS.枯草芽孢杆菌中遗传转化能力与非光复活能力之间的相关性
J Bacteriol. 1964 Jun;87(6):1295-303. doi: 10.1128/jb.87.6.1295-1303.1964.
3
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
4
Lack of SOS repair in Streptococcus pneumoniae.肺炎链球菌中缺乏SOS修复。
Mutat Res. 1980 Apr;70(2):157-65. doi: 10.1016/0027-5107(80)90155-4.
5
Influence of DNA-repair deficiencies on MMS- and EMS-induced mutagenesis in Escherichia coli K-12.DNA修复缺陷对大肠杆菌K-12中甲基磺酸甲酯（MMS）和甲基磺酸乙酯（EMS）诱导的诱变作用的影响
Mutat Res. 1981 Jul;82(2):239-50. doi: 10.1016/0027-5107(81)90153-6.
6
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Mutat Res. 1981 Oct;83(3):339-47. doi: 10.1016/0027-5107(81)90016-6.
7
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Mutat Res. 1982 Sep;99(2):129-242. doi: 10.1016/0165-1110(82)90057-4.
8
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Mol Gen Genet. 1984;193(3):561-3. doi: 10.1007/BF00382101.
9
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J Bacteriol. 1983 May;154(2):995-7. doi: 10.1128/jb.154.2.995-997.1983.
10
Mutational specificity in bacteria.细菌中的突变特异性。
Annu Rev Genet. 1983;17:215-38. doi: 10.1146/annurev.ge.17.120183.001243.
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