Rawson R A, Tennant F S
NIDA Res Monogr. 1984 Mar;49:289-95.
A group of 58 heroin addicts were treated with naltrexone and behavior therapy and followed for 5 years. At one-year post-treatment, almost half of the naltrexone-treated subjects were opiate free. Follow-up results at 5 years post-treatment indicate that over 90% of those patients treated with naltrexone became re-addicted for various periods of time. However, naltrexone-treated subjects did feel their treatment with naltrexone had provided them with the ability to remain opiate free for blocks of time. The results suggest that naltrexone is not a "cure" for opiate dependence, but is a medication which can be useful in protecting patients from re-addiction and is a modality patients should be encouraged to return to if they feel vulnerable to re-addiction.
一组58名海洛因成瘾者接受了纳曲酮治疗和行为疗法，并随访了5年。治疗后一年，几乎一半接受纳曲酮治疗的受试者未使用阿片类药物。治疗后5年的随访结果表明，超过90%接受纳曲酮治疗的患者在不同时间段内再次成瘾。然而，接受纳曲酮治疗的受试者确实觉得他们使用纳曲酮的治疗使他们有能力在一段时间内保持不使用阿片类药物。结果表明，纳曲酮并非阿片类药物依赖的“治愈方法”，而是一种有助于保护患者避免再次成瘾的药物，并且如果患者觉得自己容易再次成瘾，应鼓励他们采用这种治疗方式。
