Fischer H D, Schmidt J, Wustmann C
Biomed Biochim Acta. 1984;43(4):541-3.
The antihypoxic effect of meclofenoxate hydrochloride seen in the accelerated restitution of posthypoxic dopamine release inhibition originates in the alcoholic component of the drug. Via choline dimethylaminoethanol might run, like orotic acid, into a CDP-choline pool, the generation of which is able to be facilitated by piracetam which in turn increases the phosphorylation potential. All these nootropic drugs will in this way increase the biosynthesis of hypoxically vulnerable phospholipids by different mechanisms. Indeed, a combined treatment with piracetam, meclofenoxate hydrochloride and methylglucamineorotate leads to a more rapid restitution of posthypoxic dopamine release inhibition than the drugs are active when applied separately.
盐酸氯酯醒的抗缺氧作用表现为缺氧后多巴胺释放抑制的加速恢复，其作用源于该药物的乙醇成分。通过胆碱，二甲基氨基乙醇可能像乳清酸一样进入胞苷二磷酸胆碱池，而吡拉西坦能够促进该池的生成，进而增加磷酸化电位。所有这些益智药将通过不同机制以这种方式增加缺氧易损磷脂的生物合成。事实上，与单独使用这些药物时相比，吡拉西坦、盐酸氯酯醒和甲基葡糖胺乳清酸盐联合治疗能使缺氧后多巴胺释放抑制恢复得更快。
