甘草次酸在7,12-二甲基苯并[a]蒽加远房菌素诱导的小鼠皮肤肿瘤形成中的抗肿瘤促进活性。
Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.
作者信息
Nishino H, Kitagawa K, Iwashima A
出版信息
Carcinogenesis. 1984 Nov;5(11):1529-30. doi: 10.1093/carcin/5.11.1529.
PMID:6435904
Abstract
Glycyrrhetic acid inhibited the action of tumor promoter in vitro and in vivo. Glycyrrhetic acid inhibited the increased phospholipid metabolism of cultured cells induced by tumor promoters, 12-O-tetradecanoylphorbol-13-acetate or teleocidin, and it markedly suppressed the promoting effect of teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
摘要
甘草次酸在体外和体内均能抑制肿瘤促进剂的作用。甘草次酸可抑制由肿瘤促进剂、12-O-十四烷酰佛波醇-13-乙酸酯或杀鱼菌素诱导的培养细胞中磷脂代谢的增加，并且它能显著抑制杀鱼菌素对由7,12-二甲基苯并[a]蒽引发的小鼠皮肤肿瘤形成的促进作用。
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