用7,12-二甲基苯并(a)蒽经胎盘引发的小鼠皮肤和前胃中杀鱼菌素的促肿瘤活性。
Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene.
作者信息
Suganuma M, Fujiki H, Morino K, Takayama S, Sugimura T
出版信息
J Cancer Res Clin Oncol. 1987;113(2):123-5. doi: 10.1007/BF00391432.
Experiments on the effect of transplacental initiation with 7,12-dimethylbenz(a)anthracene (DMBA) and postnatal promotion with teleocidin were carried out in mice. The percentage of tumor-bearing mice among females treated with DMBA transplacentally on day 17 of gestation and postnatally by topical application of teleocidin to the skin of the back was 73.3% in week 30, whereas that among females treated with DMBA on day 10 of gestation and postnatally by topical application of teleocidin was 20.0%. This indicates that teleocidin shows potent tumor promoting activity on mouse skin in a transplacental initiation and postnatal promotion protocol. Furthermore, in the males treated with DMBA transplacentally on day 17 of gestation and given diet containing 0.01% teleocidin postnatally five tumors of the forestomach were found in 5 of 19 effective mice (26.3%) in week 52. One of these five tumors was a squamous cell carcinoma, and the others were papillomas. This indicates that teleocidin also has tumor promoting activity in the forestomach of mice.
在小鼠身上进行了关于经胎盘注射7,12-二甲基苯并(a)蒽（DMBA）及产后用竹桃霉素促进肿瘤发生作用的实验。在妊娠第17天经胎盘注射DMBA并在产后通过背部皮肤局部涂抹竹桃霉素处理的雌性小鼠中，在第30周时荷瘤小鼠的比例为73.3%，而在妊娠第10天经胎盘注射DMBA并在产后通过局部涂抹竹桃霉素处理的雌性小鼠中，荷瘤小鼠的比例为20.0%。这表明在经胎盘启动和产后促进方案中，竹桃霉素对小鼠皮肤显示出强大的肿瘤促进活性。此外，在妊娠第17天经胎盘注射DMBA并在产后给予含0.01%竹桃霉素饮食的雄性小鼠中，在第52周时，19只有效小鼠中有5只（26.3%）在前胃发现了5个肿瘤。这5个肿瘤中有1个是鳞状细胞癌，其他是乳头状瘤。这表明竹桃霉素在小鼠前胃中也具有肿瘤促进活性。
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