Balkwill F R, Bokhon'ko A I
Exp Cell Res. 1984 Nov;155(1):190-7. doi: 10.1016/0014-4827(84)90780-8.
Pure human alpha and recombinant gamma interferons had differential effects on two strains of fetal lung fibroblasts in vitro. Alpha interferon had little effect on long-term cell growth, whereas gamma interferons, both glycosylated and non-glycosylated, were cytotoxic. However, when synchronized cells were studied, alpha interferon prolonged both G1 and S + G2 phases of the cell cycle, whereas gamma interferon only affected the G1 phase.
纯人α干扰素和重组γ干扰素在体外对两株胎儿肺成纤维细胞有不同的作用。α干扰素对细胞的长期生长影响很小，而糖基化和非糖基化的γ干扰素均具有细胞毒性。然而，当研究同步化细胞时，α干扰素延长了细胞周期的G1期以及S + G2期，而γ干扰素仅影响G1期。
