Ota D M, Nishioka K, Foulkes M, Grossie V B
J Clin Oncol. 1984 Oct;2(10):1157-64. doi: 10.1200/JCO.1984.2.10.1157.
Changes in erythrocyte polyamine levels during intravenous hyperalimentation in cancer and noncancer patients were determined, and the influence of host nutritional status on polyamine metabolism was analyzed. RBC putrescine (P less than .001), spermidine (P less than .01), and spermine (P less than .005) levels, and the putrescine-spermidine ratio (P less than .001) increased in the cancer group while no significant increases were noted in the noncancer group. The degree of malnutrition, based on body weight loss and plasma albumin, transferrin, prealbumin, and retinol-binding protein levels, was significantly greater in the cancer group than in the noncancer group, giving rise to the possibility that repletion of nutritional deficits in host tissues could have contributed to the rise in RBC polyamines. When cancer patients of similar nutritional status were matched with the noncancer group, increases in RBC putrescine level and putrescine-spermidine ratio were noted in the selected cancer patients. These results suggest that correction of nutritional deficits did not contribute significantly to the RBC polyamine pool and that increases in RBC polyamines during intravenous hyperalimentation were related to the presence of tumor.
测定了癌症患者和非癌症患者静脉高营养期间红细胞多胺水平的变化，并分析了宿主营养状况对多胺代谢的影响。癌症组红细胞腐胺（P＜0.001）、亚精胺（P＜0.01）和精胺（P＜0.005）水平以及腐胺-亚精胺比值（P＜0.001）升高，而非癌症组未观察到显著升高。基于体重减轻以及血浆白蛋白、转铁蛋白、前白蛋白和视黄醇结合蛋白水平的营养不良程度，癌症组显著高于非癌症组，这使得宿主组织营养缺乏的补充可能导致红细胞多胺升高成为可能。当将营养状况相似的癌症患者与非癌症组进行匹配时，所选癌症患者的红细胞腐胺水平和腐胺-亚精胺比值升高。这些结果表明，营养缺乏的纠正对红细胞多胺池没有显著贡献，并且静脉高营养期间红细胞多胺的升高与肿瘤的存在有关。
