Bravo I G, Bravo M E, Plate G, Merlez J, Arancibia A
Pediatr Pharmacol (New York). 1984;4(3):167-76.
The pharmacokinetics of trimethoprim-sulphamethoxazole was examined in seven malnourished (marasmic) infants receiving cotrimoxazole (CMZ) for treatment of urinary tract infection. Comparisons were made with the SMZ level of ten nutritionally normal infants, hospitalized for first and second degree burns, receiving CMZ for treatment of bronchitis. CMZ was administered as an oral suspension (20 mg TMP and 100 mg SMZ, 5 ml), patients receiving 22 mg SMZ/kg body weight. Capillary blood samples, 0.05 ml were taken at prescribed intervals. Elimination half-life of SMZ in the marasmic infants was prolonged, 9.6 vs 4.9 hr, in their eutrophic counterparts. In addition, greater area under the curve (AUC), 573 vs 328 micrograms/ml/h, was noted in the malnourished group. This disparity may be due to differences in body fluid distribution between the two groups.
对七名营养不良（消瘦型）婴儿进行了甲氧苄啶 - 磺胺甲恶唑的药代动力学研究，这些婴儿因尿路感染接受复方新诺明（CMZ）治疗。将其与十名营养正常的婴儿的磺胺甲恶唑水平进行比较，这些营养正常的婴儿因一、二度烧伤住院，接受CMZ治疗支气管炎。CMZ以口服混悬液（20mg甲氧苄啶和100mg磺胺甲恶唑，5ml）给药，患者接受22mg磺胺甲恶唑/千克体重。按规定间隔采集0.05ml毛细血管血样。消瘦型婴儿中磺胺甲恶唑的消除半衰期延长，营养良好的婴儿为9.6小时，而营养良好的婴儿为4.9小时。此外，营养不良组的曲线下面积（AUC）更大，分别为573与328微克/毫升/小时。这种差异可能是由于两组之间体液分布的差异。
