Wagenvoort C A, Keutel J, Mooi W J, Wagenvoort N
Virchows Arch A Pathol Anat Histopathol. 1984;404(3):265-74. doi: 10.1007/BF00694892.
In lung biopsy specimens of 19 patients with congenital heart disease and pulmonary hypertension, in addition to the common features of plexogenic arteriopathy, longitudinal smooth muscle cells were found in small pulmonary arteries. These cells were arranged in bundles or layers, particularly in the intima but sometimes within the media or adventitia of the arteries. They often caused severe narrowing of the lumen. Corrective surgery of the cardiac defect was performed in 14 patients. The results suggested that even when these changes are wide-spread and severe, they do not stand in the way of a favourable post-operative course. In one patient who underwent a banding procedure of the pulmonary artery, virtually complete regression of the smooth muscle layers could be demonstrated in a second biopsy, taken 5 years later during a corrective operation.
在19例先天性心脏病合并肺动脉高压患者的肺活检标本中，除了丛状动脉病的常见特征外，在小肺动脉中还发现了纵向平滑肌细胞。这些细胞成束或成层排列，尤其在内膜，但有时也在动脉的中膜或外膜内。它们常导致管腔严重狭窄。14例患者接受了心脏缺陷矫正手术。结果表明，即使这些改变广泛且严重，也不妨碍术后有良好的病程。在1例接受肺动脉束带术的患者中，5年后在矫正手术期间进行的第二次活检显示，平滑肌层几乎完全消退。
