Wagenvoort C A, Wagenvoort N
Virchows Arch A Pathol Anat Histol. 1976 Nov 22;372(1):51-6. doi: 10.1007/BF00429716.
Lung tissue from 14 normal residents of high altitude regions, 10 patients with chronic bronchitis and emphysema, and 1 patient with Pickwickian syndrome was studied with regard to the occurrence of pulmonary vascular changes. In addition to the well-known pulmonary arterial alterations, lesions in small pulmonary veins were found in the great majority of the cases. These changes, consisting of medial hypertrophy and arterialization and of bundles of smooth muscle cells within the venous intima, have not been described before in man. These findings suggest that alveolar hypoxia acts not only on small pulmonary arteries and arterioles but also on veins of small caliber, probably by inducing venoconstriction.
对14名高海拔地区正常居民、10名慢性支气管炎和肺气肿患者以及1名匹克威克综合征患者的肺组织进行了肺血管变化发生情况的研究。除了众所周知的肺动脉改变外，在绝大多数病例中还发现了小肺静脉病变。这些变化包括中膜肥厚和动脉化以及静脉内膜内的平滑肌细胞束，此前在人类中尚未有过描述。这些发现表明，肺泡缺氧不仅作用于小肺动脉和小动脉，还可能通过诱导静脉收缩作用于小口径静脉。
