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脂肪族醇对大鼠肝脏中某些B族复合维生素的影响。

The effect of aliphatic alcohols on certain vitamins of the B-complex group in the liver of the rat.

作者信息

Shehata M, Saad S

出版信息

Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):35-9.

PMID:643739
Abstract

The effect of the oral administration of a series of aliphatic alcohols (methanol to butanol) in addition to isopropanol on the liver contents of thiamine, riboflavin, pyridoxine, niacin, and pantothenic acid was investigated in rats. It was found the tested alcohols caused a significant decrease in the liver contents of the studied vitamins. This effect was observed after daily oral administration of the tested alcohols in doses of 1 and 2 mg/kg for 7 days. The diminishing effect of alcohols on the liver contents of vitamins was directly proportional to the dose administered.

摘要

除异丙醇外，还研究了给大鼠口服一系列脂肪醇（甲醇至丁醇）对其肝脏中硫胺素、核黄素、吡哆醇、烟酸和泛酸含量的影响。发现受试醇类导致所研究维生素的肝脏含量显著降低。在以1和2毫克/千克的剂量每日口服受试醇类7天后观察到了这种效应。醇类对肝脏维生素含量的降低作用与给药剂量直接成正比。

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