Hows J M, Mehta A, Ward L, Woods K, Perez R, Gordon M Y, Gordon-Smith E C
Br J Cancer. 1984 Dec;50(6):753-6. doi: 10.1038/bjc.1984.252.
A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide induced haemorrhagic cystitis in marrow transplant recipients. Sixty-one consecutive BMT recipients were randomised for treatment with forced diuresis or mesna. The incidence of macroscopic haematuria was significantly lower in the mesna treated group (chi 2 = 4.03, P less than 0.05). No specific side effects of mesna were detected. The lymphopenia induced by cyclophosphamide in the aplastic recipients was similar in the mesna and forced diuresis groups suggesting that mesna has no effect on the lymphocytotoxic activity of cyclophosphamide, although 6 out of 7 episodes of graft failure documented in the study occurred in mesna treated patients. As a result of this study our present policy is to use mesna in all BMT recipients but to continue careful documentation of the incidence of graft failure.
开展了一项前瞻性随机研究，以比较美司钠（2-巯基乙烷磺酸钠）与强制利尿在预防骨髓移植受者环磷酰胺诱导的出血性膀胱炎方面的效果。61例连续的骨髓移植受者被随机分配接受强制利尿或美司钠治疗。美司钠治疗组肉眼血尿的发生率显著更低（χ² = 4.03，P < 0.05）。未检测到美司钠的特定副作用。在再生障碍性贫血受者中，环磷酰胺诱导的淋巴细胞减少在美司钠组和强制利尿组中相似，这表明美司钠对环磷酰胺的淋巴细胞毒性活性没有影响，尽管该研究记录的7例移植失败中有6例发生在接受美司钠治疗的患者中。基于这项研究，我们目前的策略是在所有骨髓移植受者中使用美司钠，但继续仔细记录移植失败的发生率。
