使用2-巯基乙烷磺酸钠预防环磷酰胺所致膀胱炎。
The use of sodium 2-mercaptoethane sulfonate to prevent cyclophosphamide cystitis.
作者信息
Ehrlich R M, Freedman A, Goldsobel A B, Stiehm E R
出版信息
J Urol. 1984 May;131(5):960-2. doi: 10.1016/s0022-5347(17)50729-6.
In 2 patients receiving bone marrow transplantation sodium 2-mercaptoethane sulfonate has proved efficacious in preventing the serious problem of cyclophosphamide cystitis by regional detoxification of acrolein. We detail the first use of sodium 2-mercaptoethane sulfonate in the United States. We are cautiously enthusiastic and optimistic that the simultaneous administration of sodium 2-mercaptoethane sulfonate and cyclophosphamide will decrease if not eliminate cyclophosphamide-induced carcinoma.
在2例接受骨髓移植的患者中，2-巯基乙烷磺酸钠已被证明可通过对丙烯醛进行局部解毒，有效预防环磷酰胺膀胱炎这一严重问题。我们详细介绍了2-巯基乙烷磺酸钠在美国的首次应用。我们谨慎地抱有热情和乐观态度，认为同时给予2-巯基乙烷磺酸钠和环磷酰胺即便不能消除，也会减少环磷酰胺诱发的癌症。
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