西咪替丁对肾移植后上消化道出血的影响：一项前瞻性研究。
Effect of cimetidine on upper gastrointestinal bleeding after renal transplantation: a prospective study.
作者信息
Walter S, Thorup Andersen J, Christensen U, Løkkegaard H, Kjersem H, Dahlager Jørgensen J I, Stadil F
出版信息
Br Med J (Clin Res Ed). 1984 Nov 3;289(6453):1175-6. doi: 10.1136/bmj.289.6453.1175.
In 97 consecutive patients undergoing renal transplantation the incidence of upper gastrointestinal bleeding was registered over 180 days after allocation to treatment with either cimetidine or placebo. Bleeding episodes occurred in 12 patients, 11 of whom were receiving placebo and only one cimetidine (p less than 0.01). All bleeding episodes occurred during the first month after allotransplantation. Treatment with cimetidine did not lead to an increased incidence of rejection of the allograft. It is concluded that cimetidine is effective and safe in protecting against upper gastrointestinal bleeding after renal transplantation.
在97例接受肾移植的连续患者中，记录了分配接受西咪替丁或安慰剂治疗后180天内上消化道出血的发生率。12例患者发生了出血事件，其中11例接受安慰剂治疗，仅1例接受西咪替丁治疗（p<0.01）。所有出血事件均发生在同种异体移植后的第一个月内。西咪替丁治疗并未导致同种异体移植物排斥反应发生率增加。结论是西咪替丁在预防肾移植后上消化道出血方面有效且安全。
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