6-羟基多巴胺对从大鼠大脑制备的儿茶酚胺能突触体的特异性裂解作用。
Specific lysis by 6-hydroxydopamine of catecholaminergic synaptosomes prepared from rat cerebrum.
作者信息
Suzuki T, Okumura-Noji K, Tanaka R
出版信息
Brain Res. 1984 Nov 12;321(2):374-6. doi: 10.1016/0006-8993(84)90196-3.
PMID:6437604
Abstract
The toxicity of 6-hydroxydopamine on synaptosomes prepared from rat cerebra was investigated. The drug caused synaptolysis, and the lytic effect was specific to catecholaminergic synaptosomes, since no neurotransmitters (serotonin and amino acids) other than catecholamines (dopamine and noradrenaline) were liberated by the drug.
摘要
研究了6-羟基多巴胺对从大鼠大脑制备的突触体的毒性。该药物引起突触溶解，且溶解作用对儿茶酚胺能突触体具有特异性，因为除了儿茶酚胺（多巴胺和去甲肾上腺素）外，该药物不会释放其他神经递质（血清素和氨基酸）。
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